Understanding the phytochemistry and molecular insights to the pharmacology of Angelica archangelica L. (garden angelica) and its bioactive components. (12th July 2021)

• Record Type: Journal Article
• Authors: Kaur, Anudeep; Bhatti, Rajbir
• Is Part Of: Phytotherapy research. Volume 35:Number 11(2021)
• Page Start: 5961
• Page End: 5979
• Publication Date: 2021-07-12
• Subjects: Angelica archangelica -- coumarins -- pharmacology -- phytochemistry; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.7206
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Plant‐derived molecules have enduring usefulness in treating diseases, and herbal drugs have emerged as a vital component of global therapeutic demand. Angelica archangelica L . (A. archangelica), commonly known as garden angelica, is an aromatic food plant used in culinary procedures as a flavoring agent. In the traditional medicine system, it is regarded as an "Angel plant" due to its miraculous curative power. This review aims to provide a comprehensive summary of the plant's taxonomic profile, ethnopharmacology, Phytochemistry, and pharmacological activities. Various in vivo and in vitro experiments have validated that the plant possesses broad pharmacological potential. The biological activities attributed to the plant include anti‐anxiety activity, anti‐convulsant activity, cognition enhancer, antiviral activity, cholinesterase inhibitory potential, antiinflammatory activity, gastroprotective activity, and radioprotective activity. The beneficial effects of the plant are credited to its bioactive components, that is, coumarins and volatile oils. The review summarizes the pharmacological activities of crude extract and its bioactive fractions and has also explored their target‐oriented effects. This review will be of value in undertaking further investigations on the plant with regard to exploring mechanism‐based pharmacological approaches on A. archangelica .