Induced neural progenitor cell‐derived extracellular vesicles promote neural progenitor cell survival via extracellular signal‐regulated kinase pathway. (13th October 2021)

• Record Type: Journal Article
• Authors: Ma, Yizhao; Xu, Xiaonan; Li, Chunhong; Wang, Yi; Zhu, Jie; Xia, Xiaohuan; Zheng, Jialin C.
• Is Part Of: CNS neuroscience & therapeutics. Volume 27:Number 12(2021)
• Page Start: 1605
• Page End: 1609
• Publication Date: 2021-10-13
• Subjects: Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.13744
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract : Proposed model for the anti‐apoptotic effects of induced neural stem/progenitor cell (iNPC)‐derived extracellular vesicles (EVs). iNPC release EVs that are abundantly loaded with growth factor‐related proteins. These growth factor‐enriched EVs enhance the phosphorylation of extracellular signal‐regulated kinase (ERK), but not AKt. The EV‐induced activation of ERK pathway then inhibit the apoptosis of NPCs in various pathological conditions including oxidative stress and starvation.