Repurposing colchicine's journey in view of drug-to-drug interactions. A review. (2021)

• Record Type: Journal Article
• Authors: Vrachatis, Dimitrios A.; Papathanasiou, Konstantinos A.; Giotaki, Sotiria G.; Iliodromitis, Konstantinos E.; Papaioannou, Theodore G.; Stefanini, Giulio G.; Cleman, Michael; Siasos, Gerasimos; Reimers, Bernhard; Lansky, Alexandra; Tardif, Jean-Claude; Deftereos, Spyridon G.; Giannopoulos, George
• Is Part Of: Toxicology reports. Volume 8(2021)
• Page Start: 1389
• Page End: 1393
• Publication Date: 2021
• Subjects: ACS acute coronary syndrome -- CAD coronary artery disease -- COVID-19 coronavirus disease - 19 -- eGFR estimated glomerular filtration rate -- DOACs direct oral anticoagulants -- NLRP3 NOD-, LRR- and pyrin domain-containing protein 3 -- ROCK Rho-associated protein kinase -- Lp-PLA2 Lipoprotein-associated phospholipase A2; Colchicine -- History -- Pharmacokinetics -- Inflammation -- Safety -- Repurposing; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2021.07.009
• Languages: English
• ISSNs: 2214-7500

Abstract

Graphical abstract: Highlights: Colchicine is among the oldest drug molecules in medical history. Clinicians should always check for drug to drug interactions and modify colchicine's dose according to published guidelines. Beyond known indications (e.g. pericarditis, gout), current evidence implies favorable colchicine effects in CAD, stroke and even in COVID19. Abstract: Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.