Association of blood lead level with neurobehavior and neurotransmitter expressions in Indian children. (2021)

• Record Type: Journal Article
• Authors: L., Malavika; Mitra, Prasenjit; Goyal, Taru; Abhilasha, ; Sharma, Shailja; Purohit, Purvi; Sharma, Praveen
• Is Part Of: Toxicology reports. Volume 8(2021)
• Page Start: 971
• Page End: 976
• Publication Date: 2021
• Subjects: Blood lead level -- Neurobehavior -- Neurotransmitter -- Serotonin -- Dopamine; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2021.05.002
• Languages: English
• ISSNs: 2214-7500

Abstract

Graphical abstract: Highlights: BLL had a significant direct correlation with abnormal neurobehavior. Serum serotonin levels were significantly lower in children with high blood lead levels (BLL). Serum serotonin and dopamine receptor expression were upregulated in children with high BLL. Serum serotonin levels had significant negative association with adverse neurobehavior. Dopamine receptor expression had significant positive association with adverse neurobehavior. Abstract: Present study aimed to assess the alterations in neurotransmitter expression and its association with Blood Lead Level (BLL) and neurobehavioral pattern in children. 72 school going children were recruited. Blood lead levels were determined by Atomic Absorption Spectrophotometer. Neurobehavioral state was assessed by means of population specific scale i.e. CPMS (Childhood Psychopathological measurement Schedule). Serum serotonin and dopamine were estimated by ELISA, receptor and transporter gene expressions were assessed by quantitative real time PCR. Significant positive correlation was observed between Total CPMS score (i.e. adverse neurobehaviour) and BLL. Further, serum serotonin levels and dopamine receptor expression showed a negative and positive association with BLL, respectively. In similarity, serum serotonin levels showed a negative correlation and dopamine receptor expression had a significant positive correlation with total CPMS score. Environmental exposure to Lead (Pb) may result in significant alterations in the neurotransmitter levels which may be associated with neurobehavioral changes in the children exposed to Pb.