Predicting response to treatment for colorectal cancer: a review of relevant mechanisms and potential biomarkers. (April 2015)

• Record Type: Journal Article
• Authors: Sutton, Paul A; Jones, Rob P; Evans, Jonathan P; Kitteringham, Neil; Goldring, Chris; Palmer, Dan H; Vimalachandran, Dale; Malik, Hassan Z
• Is Part Of: Colorectal cancer. Volume 4:Number 2(2015)
• Page Start: 85
• Page End: 95
• Publication Date: 2015-04
• Subjects: adjuvant -- biomarker -- cancer -- chemotherapy -- colorectal -- neoadjuvant -- personalized medicine -- radiotherapy -- treatment; Colon (Anatomy) -- Cancer -- Periodicals; Rectum -- Cancer -- Periodicals; 616.994347
• DOI: 10.2217/crc.15.11
• Languages: English
• ISSNs: 1758-194X

Abstract

Abstract : Neoadjuvant therapy for colorectal cancer offers potential oncological benefits but is associated with increased surgical risk. Predictive biomarkers would allow the personalization of this risk/benefit balance, with treatment stratified by likely response. Although current clinical application of predictive biomarkers is limited, a number of potential targets have been proposed. This review summarizes some of the approaches being used to develop predictive biomarkers for the personalization of colorectal cancer management.