Could prevention of infantile spasms have been possible in a historical cohort of 31 tuberous sclerosis patients?. (November 2021)

• Record Type: Journal Article
• Authors: Riikonen, Raili
• Is Part Of: European journal of paediatric neurology. Volume 35(2021)
• Page Start: 153
• Page End: 157
• Publication Date: 2021-11
• Subjects: Infantile spasms -- Tuberous sclerosis -- Prevention -- Retrospective study; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2021.10.010
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Efforts to prevent epilepsy in infants with tuberous sclerosis complex (TSC) has been the focus of EPISTOP. Purpose: The present study was carried out to evaluate whether prevention could have been realistic. Methods: A retrospective analysis by hospital chart review of 31 patients with TSC and infantile spasms (practically all patients) admitted to two tertiary hospitals, Children's Hospital, University of Helsinki and Kuopio in 1980–2000. Clinical history, early cognitive development, early clinical signs of TSC, clinical signs of suspicious seizures, first seizures and EEG, response to adrenocorticotropic hormone (ACTH) therapy, EEG and brain imaging were evaluated. Results: Early development prior the spasms was apparently normal in 25 (80%). The first EEG ever performed for a child showed hypsarrhythmia in 16 (51%) or modified hypsarrhythmia in 10 (32%). Treatment lag was short (0–4, mean 2 weeks) and the primary response to ACTH favorable in 19 (64%). Etiological diagnostic workup of IS revealed TSC. In one single case (3%) the diagnosis of TSC could be made at birth due to a congenital cardiac rhabdomyoma. Three other rhabomyomas were diagnosed later. In brain imaging, subependymal periventricular calcifications or hypodense areas were seen in every patient at onset of IS. Other organ manifestations of TSC were retinal phakomas (6), polycystic kidneys (2), and renal angiolipomatosis (1). Conclusions: Preventive treatment of epileptic discharges could have been possible in a single case of neonatal rhabdomyoma suggesting that preventive treatment is challenging in everyday practice. The main obstacle is the delay of TSC diagnosis. Highlights: Purpose of this study was carried out to evaluate whether prevention could have been realistic. Preventive treatment of infantile epilepsy in patients with tuberous sclerosis is challenging in everyday practice. The main obstacle is the delay of tuberous sclerosis diagnosis.