AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. Issue 11 (2nd November 2021)

• Record Type: Journal Article
• Authors: Karabiyik, Cansu; Rubinsztein, David C.
• Is Part Of: Autophagy. Volume 17:Issue 11(2021)
• Page Start: 3877
• Page End: 3878
• Publication Date: 2021-11-02
• Subjects: Autophagy -- AMPK -- PIKFYVE -- Ptdins5P -- ULK1 -- glucose starvation; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2021.1961409
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: The induction of macroautophagy/autophagy upon glucose deprivation can occur independently of the PIK3C3/VPS34 complex. Recently, we described a non-canonical signaling pathway involving the kinases AMPK, ULK1 and PIKFYVE that are induced during glucose starvation, leading to the formation of PtdIns5P-containing autophagosomes, resulting in increased autophagy flux and clearance of autophagy substrates. In this cascade, the activation of AMPK leads to ULK1 phosphorylation. ULK1 then phosphorylates PIKFYVE at S1548, leading to its activation and increased PtdIns5P formation, which enables the recruitment of machinery required for autophagosome biogenesis.