Neonatal hypoxic-ischaemic encephalopathy: Motor impairment beyond cerebral palsy. (November 2021)

• Record Type: Journal Article
• Authors: Erdi-Krausz, Gergo; Rocha, Ruben; Brown, Alice; Myneni, Archana; Lennartsson, Finn; Romsauerova, Andrea; Cianfaglione, Rina; Edmonds, Caroline.J.; Vollmer, Brigitte
• Is Part Of: European journal of paediatric neurology. Volume 35(2021)
• Page Start: 74
• Page End: 81
• Publication Date: 2021-11
• Subjects: Hypoxic-ischaemic encephalopathy -- Minor neurological dysfunction -- Neuromotor function -- Attention -- Magnetic resonance imaging; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2021.10.005
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Background: Research investigating neuromotor function in the absence of cerebral palsy (CP) for children who had neonatal HIE is limited. Aims: To investigate school-age neurological and neuromotor function, and correlations with attention, neonatal Magnetic Resonance Imaging (MRI), and neuromotor assessments at toddler age. Methods: Twenty-seven children with neonatal HIE without CP who underwent hypothermia treatment and a comparison group of 20 children were assessed at age 5–7 years for Minor Neurological Dysfunction (MND; simplified Touwen), motor skills (Movement Assessment Battery for Children-2; MABC-2), parental concern over motor function (MABC Checklist), general cognition (Wechsler Preschool and Primary Scale of Intelligence-IV, WPPSI), and attention (DuPaul ADHD Rating Scale). Neurological examination and motor development, using Bayley-3 scales, at age 24-months was extracted from the clinical database. Clinical neonatal MRI was assessed for hypoxic-ischaemic injury. Results: In the HIE group, MND was more prevalent (p = 0.026) and M-ABC performance (total score p = 0.006; balance subtest p = 0.008) was worse; parents were more concerned about children's motor function (p = 0.011). HIE group inattention scores were higher (p = 0.032), which correlated with lower MABC-2 scores (rs = −0.590, p = 0.004). Neurological examination at 24-months correlated with MND (rs = 0.437, p = 0.033); Bayley-3 motor scores did not correlate with M-ABC-2 scores (rs = 368, p = 0.133). Neonatal MRI findings were not associated with school-age MND (rs = 0.140, p = 0.523) or MABC-2 (rs = 0.300, p = 0.165). Conclusions: Children with neonatal HIE, without CP, treated with hypothermia may be more likely to develop MND and motor difficulties than typically developing peers. Inattention may contribute to motor performance. In the absence of CP, neonatal MRI and toddler age assessment of motor development have limited predictive value for school-age outcome. Since this was an exploratory study with a small sample size, findings should be confirmed by a definite larger study. Highlights: Children with HIE are more likely to develop MND and motor skills deficits. Motor and cognitive difficulties correlate with inattention measures in this population. 24-month neurological examination may predict MND at school-age. 24 months assessment of motor development did not predict motor function at school age. In the absence of CP, neonatal conventional structural MRI is not predictive of school-age neuromotor outcomes.