Neuroprotective potential of hydroethanolic hull extract of Juglans regia L. on isoprenaline induced oxidative damage in brain of Wistar rats. (2021)

• Record Type: Journal Article
• Authors: Sharma, Priyanka; Verma, Pawan K.; Sood, Shilpa; Pankaj, Nrip K.; Agarwal, Sanjay; Raina, Rajinder
• Is Part Of: Toxicology reports. Volume 8(2021)
• Page Start: 223
• Page End: 229
• Publication Date: 2021
• Subjects: Isoprenaline -- Oxidative damage -- Brain -- Juglans regia -- Lipid peroxidation; Toxicology -- Periodicals; Clinical toxicology -- Periodicals; Drug-Related Side Effects and Adverse Reactions; Hazardous Substances; Poisoning; Toxicology; Electronic journals; Periodicals; Periodicals; 571.9505
• DOI: 10.1016/j.toxrep.2021.01.006
• Languages: English
• ISSNs: 2214-7500

Abstract

Graphical abstract: Highlights: Juglans regia L. fruit is commonly used as nutraceuticals especially for development of brain tissue. Isoprenaline administration produces oxidative damage, reduced antioxidant status and cholinergic crisis along with histopathological alterations in rat brain. Hull extract administration reduced the lipid and protein peroxidation, restored antioxidant status and histopathological changes in brain induced by isoprenaline. Abstract: The study was aimed at assessing isoprenaline (ISO) induced oxidative damage in brain of Wistar rats and its protection by hydroethanolic hull extract of Juglans regia . Administration of ISO significantly increases catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), malondialdehyde (MDA) and advanced oxidation protein product (AOPP) levels and significantly reduced activities of antioxidant status (TAS), total thiols (TTH), acetylcholinesterase (AChE), arylesterase (AE), and glutathione peroxidase (GPx) in rat brain. Histopathologically, neuronal degeneration, spongiosis and gliosis were seen in cerebral cortex after ISO administration. Pretreatment with hull extract restored TAS, TTH, AChE, CAT and SOD values. Additionally, significant reductions were noted in levels of MDA, AOPP, and severity of histomorphological changes in cerebral cortex following hull extract treatment. Altered antioxidant biomarkers along with histopathological changes indicate oxidative injury in rat brain following ISO administration. Repeated administration of J. regia hull extract demonstrating presence of neuroprotective properties against ISO induced oxidative damage in rat brain.