Caged lipids for subcellular manipulation. (December 2021)

• Record Type: Journal Article
• Authors: Farley, Scotland; Laguerre, Aurélien; Schultz, Carsten
• Is Part Of: Current opinion in chemical biology. Volume 65(2021)
• Page Start: 42
• Page End: 48
• Publication Date: 2021-12
• Subjects: Photoactivation -- Fluorescence -- Signaling -- Lipid transport; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2021.04.012
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: We present recently developed strategies to manipulate lipid levels in live cells by light. We focus on photoremovable protecting groups that lead to subcellular restricted localization and activation and discuss alternative techniques. We emphasize the development of organelle targeting of caged lipids and discuss recent advances in chromatic orthogonality of caging groups for future applications.