The potential roles of natural plant polysaccharides in inflammatory bowel disease: A review. (1st February 2022)

• Record Type: Journal Article
• Authors: Yang, Wenna; Zhao, Ping; Li, Xia; Guo, Lanping; Gao, Wenyuan
• Is Part Of: Carbohydrate polymers. Volume 277(2022)
• Publication Date: 2022-02-01
• Subjects: Polysaccharides -- Inflammatory bowel disease -- Intestinal flora -- Structure-activity relationship; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118821
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Inflammatory bowel disease (IBD) is a long-term chronic disease, about 20% of IBD patients deteriorate to colorectal cancer. Currently, there is no radical cure for IBD. Natural plant polysaccharides (NPP) have low toxic and side effects, which have immune and prebiotic activities and possesses positive effect on alleviating IBD. In this review, we will focus on the alleviating effect of NPP on IBD in vitro and in vivo from three aspects: regulating intestinal flora imbalance, repairing intestinal barrier injury and improving immunity. The relationship between the chemical structure of natural plant polysaccharides and the therapeutic effect of IBD are highlighted. Finally, the synergistic role of NPP as a carrier of drugs or active molecules to reduce side effects and enhance targeting function are discussed, especially pectic polysaccharides. Broadly, this review provides a valuable reference for NPP to be developed as functional food or health products to alleviate IBD. Highlights: NPP alleviate IBD by regulating intestinal flora, intestinal barrier, and immunity. NPP rich in galactose and mannose exert more active role on IBD. Sulfurate-containing polysaccharides and pectin are more effective to improve IBD. Plant-derived polysaccharides have bright prospects as drug carriers.