Plasma mid-regional pro-atrial natriuretic peptide predicts cardiovascular events in patients with type 2 diabetes independently of subclinical organ damage. (December 2021)

• Record Type: Journal Article
• Authors: Gauffin, Emilia; Chisalita, Simona I.; Engvall, Jan; Nyström, Fredrik H.; Östgren, Carl Johan
• Is Part Of: Diabetes research and clinical practice. Volume 182(2021)
• Publication Date: 2021-12
• Subjects: Type 2 diabetes -- MR-proANP -- Cardiovascular events; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.109095
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: In our study we found that elevated value of plasma mid-regional pro-atrial natriuretic peptide (MR-proANP) predict an increased risk for major adverse cardiovascular events (MACE) and all-cause mortality in patients with type 2 diabetes independently of CVD risk factors and markers for subclinical organ damage. Our results support the use of MR-proANP in future risk algorithms for use in clinical practice for cardiovascular risk stratification of patients with type 2 diabetes. Our results support the use of MR-proANP in future risk algorithms for use in clinical practice for cardiovascular risk stratification of patients with type 2 diabetes. Abstract: Aim: The aim of this study was to investigate the association between plasma MR-proANP and cardiovascular disease (CVD) in a middle-aged population with type 2 diabetes. Methods: MR-proANP was measured in 690 patients with type 2 diabetes participating in the epidemiological study CARDIPP (Cardiovascular Risk Factors in Patients with Diabetes—a Prospective Study in Primary Care). The outcome variables were incident major adverse cardiovascular events (MACE) and all-cause mortality. Patients were followed using the national Swedish Cause of Death Registry and the Inpatient Register. Results: During the mean follow-up period of 10.8 years, MACE occurred in 111 patients and 102 patients died. The hazard ratio for an increment of MR-proANP of 1 pmol/l adjusted for sex, age, current smoking, previous CVD, HbA1c, serum cholesterol, eGFR, systolic blood pressure, C-reactive protein, aortic pulse wave velocity, left ventricular mass and intima media thickness in the carotid arteries was 1.007 (95% CI 1.000–1.013, P = 0.042) for MACE and 1.008 (95% CI 1.001–1.014, P = 0.017) for all-cause mortality. Conclusions: Elevated MR-proANP levels predict an increased risk for MACE and all-cause mortality in patients with type 2 diabetes independently of CVD risk factors and markers for subclinical organ damage.