Outstanding improvement of the advanced lipoprotein profile in subjects with new-onset type 1 diabetes mellitus after achieving optimal glycemic control. (December 2021)

• Record Type: Journal Article
• Authors: Castelblanco, Esmeralda; Hernández, Marta; Ortega, Emilio; Amigó, Núria; Real, Jordi; Granado-Casas, Minerva; Miñambres, Inka; López, Carolina; Lecube, Albert; Bermúdez-López, Marcelino; Alonso, Núria; Julve, Josep; Mauricio, Didac
• Is Part Of: Diabetes research and clinical practice. Volume 182(2021)
• Publication Date: 2021-12
• Subjects: Diabetic dyslipidemia -- Nuclear magnetic resonance (1H NMR) spectroscopy -- Cardiovascular risk -- Lipoprotein remnants -- Type 1 diabetes; ApoB apolipoprotein B -- ApoA-I apolipoprotein A-I -- Lp(a) Lipoprotein (a) -- 1H NMR nuclear magnetic resonance -- CKD-EPI Chronic Kidney Disease Epidemiology Collaboration -- CVD cardiovascular disease -- IDL intermediate-density lipoprotein -- LDL-C low-density lipoprotein cholesterol -- HDL-C high-density lipoprotein cholesterol -- NEFA non-esterified fatty acids -- T1D type 1 diabetes mellitus -- TG triglycerides -- VLDL very-low-density lipoprotein; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.109145
• Languages: English
• ISSNs: 0168-8227

Abstract

Abstract: Aims: The impact of glycemic optimization on lipoprotein subfraction parameters in apparently normolipidemic subjects with new-onset type 1 diabetes mellitus (T1D) was examined. Methods: We evaluated the serum lipid and advanced lipoprotein profiles in twenty subjects at onset of T1D and twenty non-diabetic controls by laboratory methods and 1H NMR spectroscopy shortly after diabetes diagnosis (baseline), and after achieving optimal glycemic control (HbA1c ≤ 7.0%). Results: Advanced lipoprotein analysis revealed a significant reduction from baseline in serum concentrations of triglycerides (TG), cholesterol (C), and apolipoprotein (Apo)B-containing lipoproteins of treated subjects (VLDL-TG: −21%, IDL-TG: −30%, LDL-TG: −34%, LDL-TG: −36%, P < 0.05; VLDL-C: –23%, IDL-C: −44%, LDL-C: −16%; p < 0.05). Decreased VLDL and LDL lipids were mainly attributed to concomitant reductions in the concentration of medium-sized VLDL (–36%) and medium-sized LDL (–31%) and, to a lesser extent, to large-sized LDL (–14%). Notably, proatherogenic IDL characteristics and related surrogates of atherogenicity were resolved upon achievement of optimal glycemic status. Moreover, the concentration of HDL-TG was also reduced (−18%) at follow-up. Conclusions: Our data showed that the achievement of optimal glycemic control after T1D onset corrected hidden derangements in ApoB-containing lipoproteins (particularly IDL) and HDL-TG that are related to higher cardiovascular risk in poorly controlled T1D.