Early-onset type 2 diabetes <60 years and risk of vascular complications. (December 2021)

• Record Type: Journal Article
• Authors: Yen, Fu-Shun; Lo, Yu-Ru; Hwu, Chii-Min; Hsu, Chih-Cheng
• Is Part Of: Diabetes research and clinical practice. Volume 182(2021)
• Publication Date: 2021-12
• Subjects: All-cause mortality -- Heart failure -- Microvascular disease -- Myocardial infarction -- Stroke; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2021.109129
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: People with type 2 diabetes have high risks of all-cause mortality and vascular complications. Compared to those with late-onset diabetes (disease onset after 60 years of age), persons with young-onset (disease onset before 40) and early-onset (disease onset between 40 and 60) type 2 diabetes are associated with further excess risks of death, macrovascular, microvascular complications and leg amputation. Abstract: Aim: To compare long-term outcomes among three groups with different ages of diabetes onset. Method: 66, 520 paired age-, and sex-matched persons with and without type 2 diabetes were selected from the Taiwan National Health Insurance Research Database from 2000 to 2012. Cox proportional hazards models were used to compare the outcomes. Using late-onset diabetes as a reference, adjusted difference in differences analyses were performed to assess excessive odds comparing diabetes versus non-diabetes for young-onset diabetes (YOD) and early-onset diabetes in the risks of mortality and vascular complications. Results: Persons with type 2 diabetes, irrespective of the onset age, had higher associated risks of all-cause mortality and vascular complications than their matched counterparts without diabetes. Compared to the odds of complications between those with diabetes and non-diabetes in the late-onset diabetes group, the excess odds in YOD are generally greater than in the early-onset diabetes (for stroke: 1.90 vs. 1.32; heart failure: 2.03 vs. 1.58; myocardial infarction: 3.02 vs. 1.56; and microvascular complications: 3.52 vs. 3.01). Conclusions: Diabetes with different ages of onset may imply distinct long-term health outcomes. The persons with young-onset and early-onset diabetes seem to bear excess risk for mortality and vascular complications.