Molecular Imaging of Abdominal Aortic Aneurysms with Positron Emission Tomography: A Systematic Review. (December 2021)

• Record Type: Journal Article
• Authors: Baolei, Guo; Can, Chen; Peng, Lv; Yan, Shan; Cheng, Yan; Hui, Tan; Minzhi, Lv; Daqiao, Guo; Weiguo, Fu
• Is Part Of: European journal of vascular and endovascular surgery. Volume 62:Number 6(2021)
• Page Start: 969
• Page End: 980
• Publication Date: 2021-12
• Subjects: Abdominal aortic aneurysm -- Positron emission tomography -- Systematic review; Blood-vessels -- Endoscopic surgery -- Periodicals; Blood-vessels -- Surgery -- Periodicals; Vascular Surgical Procedures -- Periodicals; Vascular Surgical Procedures -- methods -- Periodicals; Vaisseaux sanguins -- Chirurgie -- Périodiques; Vaisseaux sanguins -- Chirurgie endoscopique -- Périodiques; Blood-vessels -- Endoscopic surgery; Blood-vessels -- Surgery; Endoscopy; Electronic journals; Periodicals; Electronic journals; 617.413005
• DOI: 10.1016/j.ejvs.2021.08.010
• Languages: English
• ISSNs: 1078-5884

Abstract

Abstract : Objective: Previous studies on the relationship between positron emission tomography (PET) images and abdominal aortic aneurysm (AAA) progression have shown contradictory results, and the objective of this study was to systematically review the role of PET in predicting AAA prognosis. Data Sources: PubMed, Embase, and Web of Science were searched for studies evaluating the correlation between PET imaging results and AAA growth, repair, or rupture. Review Methods: Two authors independently performed the study search, data extraction, and quality assessment following a standard method. Results: Of the 11 studies included in this review, nine used 18 F-fluorodeoxyglucose ( 18 F-FDG) PET and computed tomography (CT) imaging, whereas the remaining two used 18 F-sodium fluoride ( 18 F-NaF) PET/CT and 18 F-FDG PET/magnetic resonance imaging (MRI). Findings from the 18 F-FDG PET/CT studies were contradictory. Six studies found no significant association or correlation, and two studies found a significant negative correlation between 18 F-FDG uptake and AAA expansion. Additionally, one study found that the 18 F-FDG uptake was statistically positively related to the expansion rate in a specific AAA subgroup whose AAAs expanded significantly. Two studies suggested that increased 18 F-FDG uptake was significantly associated with AAA repair, while the other studies either found no association between 18 F-FDG uptake and AAA rupture or repair or failed to report the occurrence of clinical events. One PET/CT study that used 18 F-NaF as a tracer showed that an increased tracer uptake was significantly associated with AAA growth and clinical events. Finally, the 18 F-FDG PET/MRI study indicated that 18 F-FDG uptake was not significantly correlated with AAA expansion. Conclusion: A definitive role for 18 F-FDG PET imaging for AAA prognosis awaits further investigation, and new PET tracers such as 18 F-NaF have the potential to be a promising method for predicting AAA clinical outcomes.