Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis. (December 2021)

• Record Type: Journal Article
• Authors: Rezaei Zonooz, Sanaz; Hasani, Motahareh; Morvaridzadeh, Mojgan; Beatriz Pizarro, Ana; Heydari, Hafez; Yosaee, Somaye; Rezamand, Gholamreza; Heshmati, Javad
• Is Part Of: Journal of functional foods. Volume 87(2021)
• Publication Date: 2021-12
• Subjects: Alpha-lipoic acid -- Oxidative stress -- Malondialdehyde -- Total antioxidant capacity; ALA alpha-lipoic acid -- OS oxidative stress -- SMD standardized mean difference -- CI confidence intervals -- MDA Malondialdehyde -- TAS total antioxidant status -- GPx Glutathione peroxidase -- SOD superoxide dismutase -- TAC total antioxidant capacity -- Ox-LDL oxidized Low Density Lipoprotein -- RCTs randomized controlled trials -- GSH Glutathione -- CAT Catalase -- NO Nitric oxide -- SDs Standard deviations -- SE Standard error -- NAFLD non-alcoholic fatty liver disease -- MS Multiple Sclerosis -- MMPs Matrix metalloproteinases -- F2α IsoP PGF2α-Isoprostanes -- 8- OHdG 8-Hydroxy-2′-deoxyguanosine -- TBARS thiobarbituric acid-reactive substances -- TRAP total reactive antioxidant potential -- LDL Low Density Lipoprotein -- ROS Reactive oxygen species; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104774
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Alpha-lipoic acid (ALA) has been recognized as a strong dietary antioxidant. ALA consumption significantly decreased Malondialdehyde (MDA). ALA supplementation is a good choice to control lipid peroxidation. Abstract: The antioxidant effect of alpha-lipoic acid (ALA) and its effect in reducing reactive oxygen species has been demonstrated in primary studies. This systematic review and meta-analysis was conducted to evaluate the impact of alpha-lipoic acid (ALA) supplementation on oxidative stress (OS) parameters. We performed a comprehensive search in major electronic databases. A random-effects model was used to pool data and calculated standard mean difference and 95% confidence intervals. Fifteen studies were included in the meta-analyses. The outcomes of this meta-analysis indicated that ALA consumption significantly decreased Malondialdehyde (MDA) levels compare to control group. We found no significant effect of ALA supplementation on other antioxidant enzymes and oxidative stress parameters. Overall, the present meta-analysis indicated that ALA supplementation might lead to an amelioration in lipid peroxidation. It can be recommended that the use of ALA supplementation in < 800 mg/day is a good choice to control lipid peroxidation.