An MeSeSO3Na reagent for oxidative aminoselenomethylation of maleimides. Issue 22 (22nd September 2021)

• Record Type: Journal Article
• Authors: Wu, Ge; Yao, Yujing; Zhang, Wenliang
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 22(2021)
• Page Start: 6259
• Page End: 6264
• Publication Date: 2021-09-22
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01252e
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Herein, we describe the design and synthesis of an MeSeSO3 Na reagent, which proved to be a versatile selenomethylation reagent for copper-catalyzed aminoselenomethylation of maleimides. Abstract : Herein, we describe the design and synthesis of an MeSeSO3 Na reagent, which proved to be a versatile selenomethylation reagent for copper-catalyzed aminoselenomethylation of maleimides. This simple and efficient catalytic system is applicable for late-stage vinylselenomethylation of secondary amine-containing pharmaceuticals and two-fold aminoselenomethylation reactions. Most importantly, the current strategy provides a direct and convenient method for the incorporation of the SeCD3 group.