Impact of the objective response to and number of cycles of platinum‐based first‐line chemotherapy for metastatic urothelial carcinoma on overall survival of patients treated with pembrolizumab. (20th September 2021)

• Record Type: Journal Article
• Authors: Kato, Minoru; Kobayashi, Takashi; Matsui, Yoshiyuki; Ito, Katsuhiro; Hikami, Kensuke; Yamada, Takeshi; Ogawa, Kosuke; Nakamura, Kenji; Sassa, Naoto; Yokomizo, Akira; Abe, Takashige; Tsuchihashi, Kazunari; Tatarano, Shuichi; Inokuchi, Junichi; Tomida, Ryotaro; Fujiwara, Maki; Takahashi, Atsushi; Matsumoto, Kazumasa; Shimizu, Kosuke; Araki, Hiromasa; Kurahashi, Ryoma; Ozaki, Yu; Tashiro, Yu; Uegaki, Masayuki; Kojima, Takahiro; Uchida, Junji; Ogawa, Osamu; Nishiyama, Hiroyuki; Kitamura, Hiroshi
• Other Names: Hatakeyama Shingo investigator.; Matsushita Yuto investigator.; Naito Sei investigator.; Shiga Masanobu investigator.; Miyake Makito investigator.; Muro Yusuke investigator.; Nakanishi Shotaro investigator.; Kato Yoichiro investigator.; Shibuya Tadamasa investigator.; Hayashi Tetsutaro investigator.; Yasumoto Hiroaki investigator.; Yoshida Takashi investigator.; Uemura Motohide investigator.; Taoka Rikiya investigator.; Kamiyama Manabu investigator.; Maruyama Satoru investigator.; Mukai Shoichiro investigator.; Tsutsumi Masakazu investigator.; Miki Jun investigator.; Okuno Tomoya investigator.; Yoshio Yuko investigator.; Matsumoto Hiroaki investigator.; Shimazui Toru investigator.; Segawa Takehiko investigator.; Karashima Takashi investigator.; Masui Kimihiko investigator.; Fukuta Fumimasa investigator.; Tashiro Kojiro investigator.; Imai Kazuto investigator.; Suekane Shigetaka investigator.; Nagasawa Seiji investigator.; Higashi Shin investigator.; Fukui Tomohiro investigator.;
• Is Part Of: International journal of urology. Volume 28:Number 12(2021)
• Page Start: 1261
• Page End: 1267
• Publication Date: 2021-09-20
• Subjects: biomarkers -- chemotherapy -- pembrolizumab -- survival -- urothelial cancer; Urology -- Periodicals; Genitourinary organs -- Periodicals; Urologic Diseases -- Periodicals; 616.6005
• DOI: 10.1111/iju.14686
• Languages: English
• ISSNs: 0919-8172

Abstract

Abstract : Objectives: To investigate the impact of the number of cycles and objective response to chemotherapy on overall survival in patients with metastatic urothelial carcinoma treated with pembrolizumab. Methods: This multicenter, retrospective study included 755 patients from 59 institutions with advanced, chemoresistant urothelial carcinoma who received pembrolizumab. The associations of the overall survival with the number of cycles and best objective response were investigated using Cox multiple regression analysis. Results: Overall, 391 patients received standard first‐line chemotherapy and pembrolizumab as a second‐line treatment, and were included in the final analysis. Of the 391 patients, 185 received less than four cycles, 134 received four to six cycles and 72 received more than six cycles of first‐line chemotherapy. An objective response (complete or partial response) to chemotherapy was observed in 145 patients (37.1%). Univariate analysis showed that the overall survival of patients who received more than six cycles or responded to chemotherapy (complete or partial response) was significantly longer than that of patients who received less than four cycles or did not respond to chemotherapy (stable or progressive disease). At multivariate levels, no correlations were observed between overall survival and the number of cycles of or the response to chemotherapy. Conclusions: Therapeutic benefit of pembrolizumab can be expected irrespective of the objective response to and number of cycles of platinum‐based first‐line chemotherapy.