CD8αα+T cells exert a pro‐inflammatory role in patients with psoriasis. Issue 4 (16th November 2021)

• Record Type: Journal Article
• Authors: Zhang, Y. Y.; Lin, Y. T.; Wang, L.; Sun, X. W.; Dang, E. L.; Xue, K.; Zhang, W. G.; Zhang, K. M.; Wang, G.; Li, B.
• Is Part Of: Skin health and disease. Volume 1:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-16
• Subjects: Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatology; Skin -- Diseases; Skin Diseases; Dermatology; Periodicals; Periodical; 616.5005
• DOI: 10.1002/ski2.64
• Languages: English
• ISSNs: 2690-442X

Abstract

Abstract: Background: Psoriasis is a common chronic inflammatory disease caused by excessive activation of CD4 + T cells, including Th17, Th1 and Th22. The role of CD8 + T cells in psoriasis pathogenesis remains poorly understood. Aim: To identify the phenotype of CD8 + T cells in patients with psoriasis and to investigate its role in the formation of lesions. Methods: The phenotype of CD8 + T cells in psoriatic lesions was detected by immunofluorescence staining. Flow cytometry was performed to detect their phenotype in peripheral blood. Thereafter, coculture of CD8αα + T cells with autogenous CD4 + T cells was performed to investigate the function of CD8αα + T cells in patients with psoriasis. Finally, pro‐inflammatory factors produced by CD8αα + T cells were examined by immunofluorescence staining and flow cytometry. Results: Compared to the CD8αβ + T cells, CD8αα + T cell infiltration in psoriatic lesions markedly increased. Moreover, epidermal CD8αα + T cells exhibited tissue‐resident memory T cells (TRM ) phenotypes and dermal CD8αα + T cells exhibited effector memory (TEM ) phenotypes in psoriatic lesions. Additionally, we found that CD8αα + T cells from patients with psoriasis did not express the markers of regulatory T cells and could promote the proliferation of CD4 + T effector cells and produce interleukin‐17 and interferon‐γ. Conclusions: Our findings demonstrate that CD8αα + T cells contribute to the pathogenesis of psoriasis by producing pro‐inflammatory factors. Abstract : We identified a new subset of CD8 + T cells, CD8αα + TRM cells, which contribute to psoriasis by producing pro‐inflammatory cytokines.