A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA. Issue 45 (19th October 2021)
- Record Type:
- Journal Article
- Title:
- A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA. Issue 45 (19th October 2021)
- Main Title:
- A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA
- Authors:
- Uchida, Satoshi
Yamaberi, Yuto
Tanaka, Masakazu
Oba, Makoto - Abstract:
- Abstract : The oligopeptide structure impacts the intracellular stability of mRNA to prolong protein expression, solving a major issue of mRNA nanomedicine. Abstract : Prolonging the duration of protein expression from mRNA is a major challenge in the development of mRNA nanomedicines. mRNA complexed with helix foldamer oligopeptides consisting of arginine and α-aminoisobutyric acids showed higher intracellular stability than that complexed with oligoarginines, thereby maintaining efficient protein translation for three days.
- Is Part Of:
- Nanoscale. Volume 13:Issue 45(2021)
- Journal:
- Nanoscale
- Issue:
- Volume 13:Issue 45(2021)
- Issue Display:
- Volume 13, Issue 45 (2021)
- Year:
- 2021
- Volume:
- 13
- Issue:
- 45
- Issue Sort Value:
- 2021-0013-0045-0000
- Page Start:
- 18941
- Page End:
- 18946
- Publication Date:
- 2021-10-19
- Subjects:
- Nanoscience -- Periodicals
Nanotechnology -- Periodicals
620.505 - Journal URLs:
- http://www.rsc.org/Publishing/Journals/NR/Index.asp ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1nr03600a ↗
- Languages:
- English
- ISSNs:
- 2040-3364
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9830.266000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 19990.xml