Circular Rims2 Deficiency Causes Retinal Degeneration (Adv. Biology 12/2021). Issue 12 (3rd December 2021)

• Record Type: Journal Article
• Authors: Sun, Lan‐Fang; Ma, Yue; Ji, Yang‐Yang; Wu, Zhen; Wang, Ya‐Han; Mou, Hao; Jin, Zi‐Bing
• Is Part Of: Advanced biology. Volume 5:Issue 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-03
• Subjects: Molecular biology -- Periodicals; Systems biology -- Periodicals; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; 660.6
• DOI: 10.1002/adbi.202170121
• Languages: English
• ISSNs: 2701-0198

Abstract

Abstract : Circular Rims2 Deficiency In article 2100906, Jin and co‐workers discover that a circular RNA, circRims2, is crucial for retinal maintenance and function. Targeted silence of circRims2, but not linear Rims2, leads to significant damages of retinal neurons in the retina. Furthermore, retinal cell apoptosis is mediated by the tumor necrosis factor signaling pathway.