N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma. (July 2015)

• Record Type: Journal Article
• Authors: Mylin, Anne K; Goetze, Jens P; Heickendorff, Lene; Ahlberg, Lucia; Dahl, Inger Marie; Abildgaard, Niels; Gimsing, Peter
• Is Part Of: Biomarkers in medicine. Volume 9:Number 7(2015)
• Page Start: 679
• Page End: 689
• Publication Date: 2015-07
• Subjects: CNP -- bone disease -- multiple myeloma -- natriuretic peptides -- renal impairment; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.15.35
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma.Materials & methods: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points.Results: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events.Conclusion: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.