Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids. Issue 23 (18th October 2021)

• Record Type: Journal Article
• Authors: Jiao, Ke-Jin; Ma, Cong; Liu, Dong; Qiu, Hui; Cheng, Bin; Mei, Tian-Sheng
• Is Part Of: Organic chemistry frontiers. Volume 8:Issue 23(2021)
• Page Start: 6603
• Page End: 6608
• Publication Date: 2021-10-18
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01219c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. Abstract : A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp 3 )–H bonds in good yields from commercially available alkyl carboxylic acids, thus providing an alternative strategy for the synthesis of dialkyl ketones. Various functional groups are tolerated under mild reaction conditions.