A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole. Issue 93 (9th November 2021)

• Record Type: Journal Article
• Authors: Matsuo, Kazuya; Thayyil, Sampreeth; Kawaguchi, Mitsuyasu; Nakagawa, Hidehiko; Tamaoki, Nobuyuki
• Is Part Of: Chemical communications. Volume 57:Issue 93(2021)
• Page Start: 12500
• Page End: 12503
• Publication Date: 2021-11-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc04905d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine–threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Abstract : Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine–threonine kinase whose inhibitors are useful for the regulation of the actomyosin system. Here, we developed a photoswitchable ROCK inhibitor based on a phenylazothiazole scaffold. The reversible trans – cis isomerization by visible light stimuli enabled us to manipulate ROCK activities in vitro and in cells.