3D Printing Scaffold Vaccine for Antitumor Immunity (Adv. Mater. 48/2021). Issue 48 (1st December 2021)

• Record Type: Journal Article
• Authors: Zhang, Yue; Xu, Jialu; Fei, Ziying; Dai, Huaxing; Fan, Qin; Yang, Qianyu; Chen, Yitong; Wang, Beilei; Wang, Chao
• Is Part Of: Advanced materials. Volume 33:Issue 48(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-01
• Subjects: 3D printing scaffold -- cancer immunotherapy -- cancer vaccine -- combination therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202170380
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Cancer Immunotherapy In article number 2106768, Chao Wang and co‐workers develop a 3D‐printed scaffold loaded with immunoregulators for enhanced cancer immunotherapy. The 3D‐scaffold with porous structure endows the system with similar functions to real lymphoid organs by the recruitment of a large number of immune cells, leading to the formation of "artificial tertiary lymphoid structures" (aTLS), which are promising sites to enhance both humoral and cellular immune responses. Efficient anticancer immunity is induced when combined with immune checkpoint blockade (ICB) to inhibit tumor growth and metastasis.