Platelet-to-lymphocyte ratio is a marker of poor prognosis in patients with diabetes mellitus and ST-elevation myocardial infarction. (March 2015)

• Record Type: Journal Article
• Authors: Hudzik, Bartosz; Szkodzinski, Janusz; Gorol, Jaroslaw; Niedziela, Jacek; Lekston, Andrzej; Gasior, Mariusz; Polonski, Lech
• Is Part Of: Biomarkers in medicine. Volume 9:Number 3(2015)
• Page Start: 199
• Page End: 207
• Publication Date: 2015-03
• Subjects: diabetes mellitus -- myocardial infarction -- platelet-to-lymphocyte ratio -- prognosis; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.100
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: Platelet-to-lymphocyte ratio (PLR) has emerged as a strong marker of worse outcomes. We determined the association between PLR and clinical outcomes in patients with diabetes mellitus and ST-elevation myocardial infarction.Methods: Five hundred and twenty three patients were enrolled. Low PLR (group 1, n = 349) was defined as ≤124 and high PLR (group 2, n = 174) as >124.Results: In-hospital and 1-year mortality was higher in group 2. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting in-hospital (PLR cut-off >155) and long-term (PLR cut-off >146) death. PLR remained an independent risk factor of early and late mortality.Conclusion: PLR proved to have good prognostic value for in-hospital and late mortality. PLR cut-off value for predicting in-hospital mortality was higher to that predicting late mortality. PLR remained an independent risk factor early and late mortality.