Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis. (March 2015)

• Record Type: Journal Article
• Authors: Paquet, Éric R; Hovington, Hélène; Brisson, Hervé; Lacombe, Cédric; Larue, Hélène; Têtu, Bernard; Lacombe, Louis; Fradet, Yves; Lebel, Michel
• Is Part Of: Biomarkers in medicine. Volume 9:Number 3(2015)
• Page Start: 187
• Page End: 197
• Publication Date: 2015-03
• Subjects: bladder cancer -- disease outcome -- immunohistochemistry -- prognostic biomarker -- RPS4X -- YB-1; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.115
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: We determined whether the Y-box binding protein-1 (YB-1) and its binding partner, the X-linked ribosomal protein S4 (RPS4X), are associated with clinical outcome in bladder cancer.Materials & methods: A population of 167 patients with muscle-invasive bladder tumor without evidence of metastasis at time of cystectomy was analyzed retrospectively. YB-1 and RPS4X expressions were evaluated immunohistochemically in tumors and analyzed for association with clinical variables and survival.Results: Kaplan–Meier and multivariate Cox regression analyses indicated that low expression of RPS4X was associated with a higher risk of death or disease recurrence. In contrast, YB-1 was not significantly associated with either recurrence-free or overall survival.Conclusion: Low RPS4X expression is associated with poor disease-specific and recurrence-free survival in bladder cancer.