Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study. (February 2015)

• Record Type: Journal Article
• Authors: Ravina, Bernard; Eberly, Shirley; Oakes, David; Lang, Anthony E; Dodelet, Vince; Roos, Pieter; Harman, Jennifer; Shoulson, Ira; Schipper, Hyman M
• Is Part Of: Biomarkers in medicine. Volume 9:Number 2(2015)
• Page Start: 89
• Page End: 97
• Publication Date: 2015-02
• Subjects: biomarker -- diagnosis -- near-infrared spectroscopy -- oxidative stress -- Parkinson's disease -- plasma; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.103
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: There are no established chemical biomarkers of idiopathic Parkinson's disease (PD). The results of a prior metabolomics-based biomarker study suggested that near-infrared spectroscopy of blood plasma samples may distinguish idiopathic PD from neurologically normal controls.Methods: Near-infrared spectroscopy was used to detect and quantify substrate modifications in blood plasma samples derived from 71 PD subjects enrolled in the PostCEPT observational study and 68 normal control subjects.Results: Near-infrared spectra values were significantly higher in the PD group compared with the control group when adjusted for age and gender (PD: adjusted mean 0.49 [95% CI: 0.45–0.53]; control: adjusted mean 0.40 [95% CI: 0.36–0.44]; p = 0.004, multiple regression).Conclusion: Near-infrared spectra of blood plasma in early-stage idiopathic PD differ from those of non-neurological control subjects. However, the degree of overlap between the groups limits the use of this technique in its present form as a PD biomarker for routine clinical practice.