Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica. (February 2015)

• Record Type: Journal Article
• Authors: Baigildina, Asia A; Khaiboullina, Svetlana F; Martynova, Ekaterina V; Anokhin, Vladimir A; Lombardi, Vincent C; Rizvanov, Albert A
• Is Part Of: Biomarkers in medicine. Volume 9:Number 2(2015)
• Page Start: 99
• Page End: 107
• Publication Date: 2015-02
• Subjects: cytokine -- Hantavirus -- HRFS -- nephropathia epidemica -- Puumala virus; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.88
• Languages: English
• ISSNs: 1752-0363

Abstract

Aims: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus . The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE.Materials & methods: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations.Results: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation.Conclusion: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.