Selective HLA restriction enables the evaluation and interpretation of immunogenic breadth at comparable levels to that observed with broader HLA distribution. Issue 17 (1st August 2021)

• Record Type: Journal Article
• Authors: Hare, Jonathan; Fiore‐Gartland, Andrew; McGowan, Edward; Hunter, Eric; Gilmour, Jill; Nielsen, Morten
• Is Part Of: Proteomics. Volume 21:Issue 17/18(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-01
• Subjects: HLA diversity -- HLA frequency -- immunogenic breath -- predicted T‐cell epitopes; Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.202100121
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract: Existing approaches to identifying predictive T‐cell epitopes have traditionally utilized either 2‐digit HLA super‐families or more commonly utilizing autologous HLA alleles to facilitate the predictions. However, the use of these criteria may not consider the HLA representation within any target population. Here we propose a modification to concept of utilizing autologous HLA whereby subsets of individuals are selected for their specific HLA allele profiles and the representation they provide within a given population. Using this selective approach to HLA selection and the linkages to specific individuals may enable the design of more targeted experimentalstrategies.