Generalised tissue abnormality of aryl hydrocarbon hydroxylase in psoriasis. Issue 6251 (15th November 1980)

• Record Type: Journal Article
• Authors: Chapman, P H; Kersey, P J; Keys, B; Shuster, S; Rawlins, M D
• Is Part Of: BMJ. Volume 281:Issue 6251(1980)
• Page Start: 1315
• Page End: 1316
• Publication Date: 1980-11-15
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.281.6251.1315
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Microsomal aryl hydrocarbon hydroxylase (AHH) activity and inducibility were measured in jejunal mucosa, liver, and lesion-free epidermis of patients with psoriasis. In all three tissues AHH activity and inducibility were less than in controls. This demonstration of a generalised enzymatic abnormality in the tissues of patients with psoriasis is in keeping with the suggestion that it may be close to the underlying genetic defect.