A novel molecularly imprinted electrochemical sensor based on a nitrogen-doped graphene oxide quantum dot and molybdenum carbide nanocomposite for indometacin determination. Issue 23 (27th October 2021)

• Record Type: Journal Article
• Authors: Lu, Huan; Cui, Hanyue; Duan, Dingding; Li, Li; Ding, Yaping
• Is Part Of: Analyst. Volume 146:Issue 23(2021)
• Page Start: 7178
• Page End: 7186
• Publication Date: 2021-10-27
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d1an01665b
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : An efficiently prepared innovative electrochemical sensor based on Mo2 C-embedded N-GOQDs (N-GOQDs–Mo2 C) and a molecularly imprinted polymer showed a highly sensitive detection performance for indometacin within a relatively wide linear range. Abstract : In this work, nitrogen-doped graphene oxide quantum dots (N-GOQDs) were embedded into Mo2 C to prepare a nanocomposite with great electrical conductivity and a large specific surface area. We manufactured an innovative electrochemical sensor based on N-GOQDs–Mo2 C and a molecularly imprinted polymer (MIP) for the highly sensitive detection of indometacin (IDMC). The MIP was synthesized by electropolymerization using acrylamide as the functional monomer and IDMC as the template molecule. N-GOQDs–Mo2 C was organized by an elementary hydrothermal approach and characterized by SEM, TEM, XRD and FT-IR. In the first-rank experimental conditions, the MIP electrochemical sensor shows a wide linear range from 10 −15 M to 10 −5 M for IDMC detection and the detection limit is as low as 9.508 × 10 −16 M. Additionally, the manufactured sensor shows great selectivity for indometacin, excellent repeatability and stableness. The sensor can be applied to the detection of indometacin in tablets and water samples with fulfilling consequence.