Adherence and persistence in the use of statins and ezetimibe over 8 years in a real-life study. (2nd December 2021)

• Record Type: Journal Article
• Authors: Santoleri, Fiorenzo; Romagnoli, Alessia; Costantini, Alberto
• Is Part Of: Current medical research and opinion. Volume 37:Number 12(2021)
• Page Start: 2061
• Page End: 2066
• Publication Date: 2021-12-02
• Subjects: Adherence -- persistence -- drug-used study -- statins; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2021.1980777
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Background: Adherence and persistence to treatment are crucial in statin therapy as they are synonymous with efficacy and quality of care. The aim of this study was the real-life assessment of adherence and persistence over eight years in treatment-naive patients receiving atorvastatin, lovastatin, simvastatin, pravastatin, ezetimibe. Methods: Adherence to treatment was calculated using the 'proportion of days covered' method and persistence as the difference between the start and end of the therapy under study. Results: Treatment adherence was consistently above 85% for all drugs under study in each year. Treatment persistence was shown to half halved already from the first year. Conclusion: Adherent patients had a higher persistence than non-adherent patients.