Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides. Issue 93 (9th November 2021)

• Record Type: Journal Article
• Authors: Rotella, Madeline E.; Sar, Dinabandhu; Liu, Lei; Gutierrez, Osvaldo
• Is Part Of: Chemical communications. Volume 57:Issue 93(2021)
• Page Start: 12508
• Page End: 12511
• Publication Date: 2021-11-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc04619e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A three-component iron-bisphosphine-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. Abstract : An iron-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. In particular, aryl- and alkyl vinyl ethers are used as effective linchpins to couple alkyl or (fluoro)alkyl halides and sp 2 -hybridized Grignard nucleophiles. Preliminary results demonstrate the ability to engage thioethers as linchpins and control enantioselectivity in these transformations, an area which is largely unexplored in iron-catalyzed three-component cross-coupling reactions.