Metal-free, visible-light driven C–H ketoalkylation of glycine derivatives and peptides. Issue 23 (10th November 2021)

• Record Type: Journal Article
• Authors: Xin, Hong; Yuan, Zi-Hang; Yang, Mingyu; Wang, Ming-Hua; Duan, Xin-Hua; Guo, Li-Na
• Is Part Of: Green chemistry. Volume 23:Issue 23(2021)
• Page Start: 9549
• Page End: 9553
• Publication Date: 2021-11-10
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc03230e
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A metal free, visible-light driven C–H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides diverse unnatural amino acids bearing a distal carbonyl group in moderate to good yields. Abstract : A metal-free, visible-light driven C–H ketoalkylation of glycine derivatives and peptides with cycloalkyl hydroperoxides is presented. This protocol provides a straightforward route to unnatural amino acids bearing a distal carbonyl group with moderate to good yields. Preliminary mechanistic studies revealed that both a SET event and radical chain propagation were involved in this transformation.