MicroRNA variants in endometriosis and its severity. Issue 4 (2nd October 2021)

• Record Type: Journal Article
• Authors: Farsimadan, M; Ismail Haje, M; Khudhur Mawlood, C; Arabipour, I; Emamvirdizadeh, A; Takamoli, S; Masumi, M; Vaziri, H
• Is Part Of: British journal of biomedical science. Volume 78:Issue 4(2021)
• Page Start: 206
• Page End: 210
• Publication Date: 2021-10-02
• Subjects: Endometriosis -- microRNAs -- polymorphism; Medical sciences -- Periodicals; Medical technology -- Periodicals; Biological Science Disciplines; Clinical Laboratory Techniques; Medical Laboratory Science; Anatomie pathologique; Medical sciences; Medical technology; Klinische chemie; Laboratoriumonderzoek; Periodicals; Periodicals; 616.0756; 610.07 M489L
• DOI: 10.1080/09674845.2021.1889157
• Languages: English
• ISSNs: 0967-4845

Abstract

ABSTRACT: Background : MicroRNAs (miRNAs) are naturally occurring posttranscriptional regulatory molecules that potentially play a role in endometriotic lesion development. Method : We evaluated the prevalence of miRNAs variants miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, and miR-499 rs3746444 in endometriosis in 260 cases and 260 controls. DNA was extracted and genotyping of the SNPs was carried out by PCR. Results : There was a significant association of rs2910164 and rs2292832 with increased rates of endometriosis under the dominant (p < 0.001), recessive (p < 0.05), co-dominant (p < 0.001), and allelic model (p < 0.001). Also, rs3746444 showed a borderline association with endometriosis under the recessive model (p = 0.05); however, rs11614913 was not linked to endometriosis. Further analysis indicated the significant association of miR-146a rs2910164 polymorphism genotypes (GG, GC, and CC) and miR-149 rs2292832 genotypes (CC and CT) with endometriosis severity in patients (p < 0.001). Additionally, haplotype frequency in cases compared to controls and Linkage disequilibrium (LD) between the mentioned SNPs was appraised. Conclusion : MiR-146a, miR-149 and miR-499 may have a role in the pathogenesis of endometriosis.