Design and Synthesis of Sulfonamide‐Attached 2‐(Isoxazol‐3‐yl)‐1H‐imidazoles as Anticancer Agents. Issue 26 (9th July 2020)

• Record Type: Journal Article
• Authors: Dende, Satheesh Kumar; Korupolu, Raghu Babu; Leleti, Krishnakanth Reddy
• Is Part Of: ChemistrySelect. Volume 5:Issue 26(2020)
• Page Start: 7919
• Page End: 7922
• Publication Date: 2020-07-09
• Subjects: Imidazoles -- Oxazoles -- Sulfonamides -- cytotoxicity -- anticancer activity; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202001449
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Library of 2‐(isoxazol‐3‐yl)‐1 H ‐imidazole sulfonamide derivatives (4 a‐j) has been synthesized and structures were confirmed by 1 HNMR, 13 CNMR and mass spectral analysis. Further these compounds were tested for their anticancer activity against four human cancer cell lines, such as MCF‐7 (breast cancer), A549 (lung cancer), Colo‐205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as positive control. Among them, compounds 4 b, 4 c, 4 d, 4 e, 4 g, 4 h and 4 i showed more potent anticancer activity against human cancer cell lines. Abstract : Anticancer activity of 2‐(isoxazol‐3‐yl)‐1 H ‐imidazole sulfonamide derivatives (4a‐j) against human cancer cell lines, such as MCF‐7 (breast cancer), A549 (lung cancer), Colo‐205 (colon cancer) and A2780 (ovarian cancer) by MTT assay studied and compounds 4b‐e, 4g‐i showed more potent activity.