Divergent Ritter-type amination via photoredox catalytic four-component radical-polar crossover reactions. Issue 23 (10th November 2021)

• Record Type: Journal Article
• Authors: Guo, Sheng-Qiang; Yang, Hui-Qing; Wang, Ai-Lian; Jiang, Yu-Zhen; Xu, Guo-Qiang; Luo, Yong-Chun; Chen, Zhao-Xu; Xu, Peng-Fei
• Is Part Of: Green chemistry. Volume 23:Issue 23(2021)
• Page Start: 9571
• Page End: 9576
• Publication Date: 2021-11-10
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc03048e
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Divergent Ritter-type amination via photoredox catalytic four-component radical-polar crossover reactions with high atom-, step- and redox economy. Abstract : A green and practical divergent Ritter-type amination via a photoredox catalytic four-component radical-polar crossover process was developed. This versatile protocol presents a modular and powerful strategy to access functionalized β -sulfonyl imides and imines under mild conditions from readily available and stable substrates with high atom-, step- and redox economy. We manipulated carboxylic acids and benzotriazoles to precisely attack the nitrilium ion instead of the carbocation, thus preventing many complicated side reactions of the photocatalytic reactions. Furthermore, the synthetic utility of this divergent Ritter reaction is further demonstrated by the late-stage modification of pharmaceutical and natural product derivatives.