An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir. Issue 50 (22nd September 2021)
- Record Type:
- Journal Article
- Title:
- An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir. Issue 50 (22nd September 2021)
- Main Title:
- An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir
- Authors:
- Moorthy, Ramkumar
Kennelly, Samantha A.
Rodriguez, Deborah J.
Harki, Daniel A. - Abstract:
- Abstract : Remdesivir in RNA: An efficient synthesis of a GS-441524 -containing phosphoramidite for solid-phase RNA synthesis is reported. Abstract : Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.
- Is Part Of:
- RSC advances. Volume 11:Issue 50(2021)
- Journal:
- RSC advances
- Issue:
- Volume 11:Issue 50(2021)
- Issue Display:
- Volume 11, Issue 50 (2021)
- Year:
- 2021
- Volume:
- 11
- Issue:
- 50
- Issue Sort Value:
- 2021-0011-0050-0000
- Page Start:
- 31373
- Page End:
- 31376
- Publication Date:
- 2021-09-22
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1ra06589k ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 19937.xml