Chirality from d-guanosine to l-guanosine shapes a stable gel for three-dimensional cell culture. Issue 96 (4th November 2021)

• Record Type: Journal Article
• Authors: Du, Yuqi; Liu, Tiannan; Tang, Fan; Jin, Xin; Zhao, Hang; Liu, Jiang; Zeng, Xin; Chen, Qianming
• Is Part Of: Chemical communications. Volume 57:Issue 96(2021)
• Page Start: 12936
• Page End: 12939
• Publication Date: 2021-11-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc09911e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Alteration of chirality leads to more stable hydrogels with favorable biocompatibility and biodegradability for three-dimensional cell culture. Abstract : It is proved that l -guanosine (l -G) as an enantiomer of d -guanosine (d -G) forms more stable gels than d -G, suggesting that alteration of chirality may be a new strategy for improving the lifetime stability of supramolecular hydrogels. Experiments for three-dimensional cell culture reveal that the l -G gel is a candidate for the extracellular matrix.