Mechanical Pain Sensitivity in Postamputation Pain. Issue 1 (6th January 2022)
- Record Type:
- Journal Article
- Title:
- Mechanical Pain Sensitivity in Postamputation Pain. Issue 1 (6th January 2022)
- Main Title:
- Mechanical Pain Sensitivity in Postamputation Pain
- Authors:
- Beisheim-Ryan, Emma H.
Pohlig, Ryan T.
Hicks, Gregory E.
Horne, John R.
Medina, Jared
Sions, Jaclyn M. - Abstract:
- Abstract : Supplemental Digital Content is available in the text. Abstract : Objectives: Postamputation, clinical markers of pain-related peripheral and central nervous system hypersensitivity remain understudied. This study aimed to identify whether adults with postamputation pain demonstrate greater pain sensitivity in primary (ie, amputated region) and secondary (ie, nonamputated region) sites, as compared with pain-free peers and controls with intact limbs. Methods: Ninety-four participants postunilateral, transtibial amputation (59 with pain, 35 pain-free) and 39 controls underwent pain-pressure threshold (PPT) testing at 10 sites. Pain-pressure thresholds were normalized to sex-specific control data using Z score conversions. Normalized primary-site and secondary-site PPTs were compared between groups using multivariate analysis of variance ( P <0.050). Results: Compared with pain-free peers, adults with postamputation pain demonstrated reduced normalized PPTs across primary and secondary sites (mean difference=0.61-0.74, P =0.001 to 0.007). Compared with controls, adults with postamputation pain demonstrated reduced normalized PPTs (mean difference=0.52, P =0.026) only at primary sites. Discussion: Adults with postamputation pain demonstrate greater amputated region pain sensitivity as compared with pain-free peers or controls with intact limbs, indicating peripheral sensitization persists even after limb healing. Secondary-site pain sensitivity was similar betweenAbstract : Supplemental Digital Content is available in the text. Abstract : Objectives: Postamputation, clinical markers of pain-related peripheral and central nervous system hypersensitivity remain understudied. This study aimed to identify whether adults with postamputation pain demonstrate greater pain sensitivity in primary (ie, amputated region) and secondary (ie, nonamputated region) sites, as compared with pain-free peers and controls with intact limbs. Methods: Ninety-four participants postunilateral, transtibial amputation (59 with pain, 35 pain-free) and 39 controls underwent pain-pressure threshold (PPT) testing at 10 sites. Pain-pressure thresholds were normalized to sex-specific control data using Z score conversions. Normalized primary-site and secondary-site PPTs were compared between groups using multivariate analysis of variance ( P <0.050). Results: Compared with pain-free peers, adults with postamputation pain demonstrated reduced normalized PPTs across primary and secondary sites (mean difference=0.61-0.74, P =0.001 to 0.007). Compared with controls, adults with postamputation pain demonstrated reduced normalized PPTs (mean difference=0.52, P =0.026) only at primary sites. Discussion: Adults with postamputation pain demonstrate greater amputated region pain sensitivity as compared with pain-free peers or controls with intact limbs, indicating peripheral sensitization persists even after limb healing. Secondary-site pain sensitivity was similar between controls and adults with postamputation pain, suggesting central nervous system hypersensitivity may not be ubiquitous with postamputation pain. Studies are needed to investigate mechanisms underlying pain sensitivity differences between adults with and without postamputation pain. … (more)
- Is Part Of:
- Clinical journal of pain. Volume 38:Issue 1(2022)
- Journal:
- Clinical journal of pain
- Issue:
- Volume 38:Issue 1(2022)
- Issue Display:
- Volume 38, Issue 1 (2022)
- Year:
- 2022
- Volume:
- 38
- Issue:
- 1
- Issue Sort Value:
- 2022-0038-0001-0000
- Page Start:
- 23
- Page End:
- 31
- Publication Date:
- 2022-01-06
- Subjects:
- phantom limb pain -- persistent postsurgical pain -- pain assessment -- amputation -- mechanical hyperalgesia
Pain -- Periodicals
Pain -- Treatment -- Periodicals
Analgesia -- Periodicals
616.047205 - Journal URLs:
- http://journals.lww.com/clinicalpain/pages/default.aspx ↗
http://ovidsp.tx.ovid.com/sp-3.8.1a/ovidweb.cgi?&S=KBIDFPKNAEDDLKHNNCOKIBOBIMNEAA00&Browse=Toc+Children%7cNO%7cS.sh.2.14.27%7c629%7c50 ↗
http://www.clinicalpain.com ↗
http://journals.lww.com ↗ - DOI:
- 10.1097/AJP.0000000000000989 ↗
- Languages:
- English
- ISSNs:
- 0749-8047
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3286.294200
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 19939.xml