Noroviruses: epidemiology, immunity and prospects for prevention. (January 2015)

• Record Type: Journal Article
• Authors: Pringle, Kimberly; Lopman, Benjamin; Vega, Everardo; Vinje, Jan; Parashar, Umesh D; Hall, Aron J
• Is Part Of: Future microbiology. Volume 10:Number 1(2015:Jan.)
• Page Start: 53
• Page End: 67
• Publication Date: 2015-01
• Subjects: Caliciviridae -- GII.4 -- herd immunity -- norovirus -- vaccine; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.14.102
• Languages: English
• ISSNs: 1746-0913

Abstract

ABSTRACT : In recent years, noroviruses have become recognized as an important cause of both sporadic and epidemic acute gastroenteritis (AGE), largely due to the improved availability of broadly reactive real-time RT-PCR (TaqMan-based RT-PCR) assays. While there is substantial diversity among noroviruses, one specific genotype, GII.4, is the most common etiology in sporadic and epidemic AGE. Outbreaks of norovirus AGE most commonly occur in healthcare facilities and restaurants and result in significant morbidity and mortality and substantial healthcare costs. Norovirus vaccine development is progressing, and Phase I and II human trials have shown proof-of-principle that norovirus vaccines can reduce illness and infection.