Port delivery system: a novel drug delivery platform to treat retinal diseases. (2nd November 2021)

• Record Type: Journal Article
• Authors: Khanani, Arshad M.; Aziz, Aamir A.; Weng, Christina Y.; Lin, Weijie Violet; Vannavong, Jordyn; Chhablani, Jay; Danzig, Carl J.; Kaiser, Peter K.
• Is Part Of: Expert opinion on drug delivery. Volume 18:Number 11(2021)
• Page Start: 1571
• Page End: 1576
• Publication Date: 2021-11-02
• Subjects: Age-related macular degeneration -- anti-vegf -- intravitreal injection -- macular edema -- neovascular -- portal delivery system -- ranibizumab; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2021.1968826
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Retinal disease treatment delivery is mostly limited to intravitreal injections and slow-release injectable implants due to structural barriers in the eye, and carry associated adverse effects and relatively high treatment burden. The Port Delivery System with ranibizumab (PDS) is a novel drug delivery device that is surgically implanted into the vitreous cavity and allows for continuous release of the anti-vascular endothelial growth factor (anti-VEGF) ranibizumab, eliminating the need for frequent intravitreal injections while maintaining therapeutic intraocular drug levels to control disease activity. Investigations of PDS are summarized in this review. Areas covered: The most recent reported findings from preliminary studies and phase I–III trials are reviewed. We discuss the ramifications of these studies and the future potential for PDS in the treatment of retinal diseases. Expert opinion: PDS is a novel drug delivery platform for the treatment of retinal diseases. Currently, the data from the PDS has shown promising efficacy and ability to substantially mitigate treatment burden while effectively generating visual and anatomic outcomes similar to those in patients receiving the standard monthly ranibizumab for neovascular age-related macular degeneration. Further studies are ongoing to investigate this novel drug delivery system in other disease states.