Successful Management of Catastrophic Thrombotic Storm in a Young Boy: A Case Report From Northern India. Issue 8 (3rd November 2021)

• Record Type: Journal Article
• Authors: Jindal, Ankur K.; Ahluwalia, Jasmina; Suku, Rajiv; Suri, Deepti; Nuytemans, Karen; Ortel, Thomas L.; Pericak-Vance, Margaret A.; Vance, Jeffery M.; Singh, Surjit
• Is Part Of: Journal of pediatric hematology/oncology. Volume 43:Issue 8(2021)
• Page Start: e1132
• Page End: e1135
• Publication Date: 2021-11-03
• Subjects: chondroitin sulfate -- heparin -- pediatric -- thrombotic storm; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000002069
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Supplemental Digital Content is available in the text. Abstract : Thrombotic storm is a rare clinical entity characterized by acute to subacute thrombosis developing at multiple sites over a few days to a few weeks. An 11-year-old boy presented with headache and facial nerve palsy. He was found to have cortical sinus venous thrombosis and was initiated on low molecular weight heparin, but rapidly progressed with thromboses involving the pulmonary arteries and deep veins of the legs. Thereafter managed on high-dose unfractionated heparin, he eventually stabilized after a hospital stay of 34 days. Genetic analysis showed potentially pathogenic variants in the factor V and stabilin-2 genes.