Distinct Basal Brain Functional Activity and Connectivity in the Emotional-Arousal Network and Thalamus in Patients With Functional Constipation Associated With Anxiety and/or Depressive Disorders. Issue 7 (14th September 2021)

• Record Type: Journal Article
• Authors: Li, Guanya; Zhang, Wenchao; Hu, Yang; Wang, Jia; Li, Jingyuan; Jia, Zhenzhen; Zhang, Lei; Sun, Lijuan; von Deneen, Karen M.; Duan, Shijun; Wang, Huaning; Wu, Kaichun; Fan, Daiming; Cui, Guangbin; Zhang, Yi; Nie, Yongzhan
• Is Part Of: Psychosomatic medicine. Volume 83:Issue 7(2021)
• Page Start: 707
• Page End: 714
• Publication Date: 2021-09-14
• Subjects: functional constipation -- fMRI -- emotional-arousal -- somatic/sensory -- DMPFC = dorsomedial prefrontal cortex -- fALFF = fractional amplitude of low-frequency fluctuation -- FC = functional constipation -- FCAD = functional constipation associated with anxiety/depressive status -- FCNAD = functional constipation without anxiety/depressive status -- FGID = functional gastrointestinal disorder -- fMRI = functional magnetic resonance imaging -- HIPP = hippocampal gyrus -- IBS = irritable bowel syndrome -- OFC = orbitofrontal cortex -- pACC = perigenual anterior cingulate cortex -- PreCen = precentral gyrus -- PostCen = postcentral gyrus -- SAS = Zung Self-rating Anxiety Scale -- SDS = Zung Self-rating Depressive Status Scale -- THA = thalamus; Medicine, Psychosomatic -- Periodicals; 616.0805
• DOI: 10.1097/PSY.0000000000000958
• Languages: English
• ISSNs: 0033-3174

Abstract

Abstract : Supplemental digital content is available in the text. ABSTRACT: Objective: Functional constipation (FC) is a common gastrointestinal disorder. Anxiety and/or depressive disorders are common in patients with FC (FCAD). Brain dysfunction may play a role in FC, but the contribution of comorbid anxiety and/or depression in patients with FC is poorly understood. Methods: Sixty-five FC patients and 42 healthy controls (HCs) were recruited, and a hierarchical clustering algorithm was used to classify FC patients into FCAD and patients without anxiety/depressive status (FCNAD) based on neuropsychological assessment. Resting-state functional magnetic resonance imaging measures including fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity were used to investigate brain functional differences. Results: Thirty-seven patients were classified as FCAD, and 28 patients were classified as FCNAD; as compared with HC, both groups showed decreased activity (fALFF) in the perigenual anterior cingulate cortex (pACC), dorsomedial prefrontal cortex (DMPFC), and precuneus; enhanced precentral gyrus–thalamus connectivity and attenuated precuneus-thalamus connectivity in FCAD/FCNAD highlighted the thalamus as a critical connectivity node in the brain network ( p FWE < .05). In comparison with FCNAD/HC, the FCAD group also had decreased fALFF in the orbitofrontal cortex (OFC) and thalamus, and increased OFC-hippocampus connectivity. In the FCNAD group, brain activities (pACC/DMPFC) and connection (precuneus-thalamus) had correlations only with symptoms; in the FCAD group, brain activities (OFC, pACC/DMPFC) and connectivities (OFC-hippocampus/precentral gyrus–thalamus) showed correlations with both constipation symptoms and anxiety/depressive status ratings. Mediation analysis indicated that the relationship between abdominal distension and OFC activity was completely mediated by anxiety in FCAD. Conclusions: These findings provide evidence of differences in brain activity and functional connectivity between FCAD and FCNAD, potentially providing important clues for improving treatment strategies.