Cholesterol Granuloma: Unusual Pitfall for Hodgkin Lymphoma Evaluation With 18F-FDG PET/CT. (October 2021)

• Record Type: Journal Article
• Authors: Bahri, Haifa; Chassagne-Clement, Catherine; Michallet, Anne-Sophie; Mognetti, Thomas; Nicolas-Virelizier, Emmanuelle
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 10(2021)
• Page Start: e518
• Page End: e520
• Publication Date: 2021-10
• Subjects: cholesterol granuloma -- Hodgkin disease -- 18F-FDG PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003740
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: Cholesterol granuloma (CG) is a foreign body–type granuloma that forms in response to cholesterol crystals. Its etiology and pathogenesis are unclear. 18 F-FDG is not a tumor-specific agent. Fibroblasts, macrophages, and multinucleated giant cells also take up 18 F-FDG. Like sarcoid granulomas or fibrous dysplasia, CG avidly takes up 18 F-FDG and can mimic tumor involvement. We present 2 cases of histologically proven CG, which has been misinterpreted as active residual Hodgkin lymphoma lesion.