Associations of plasma PAPP-A2 and genetic variations with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. Issue 9 (26th September 2021)

• Record Type: Journal Article
• Authors: Wang, Yang; Jia, Hao; Gao, Wei-Hua; Zou, Ting; Yao, Shi; Du, Ming-Fei; Zhang, Xiao-Yu; Chu, Chao; Liao, Yue-Yuan; Chen, Chen; Wang, Dan; Ma, Qiong; Hu, Jia-Wen; Wang, Ke-Ke; Yan, Yu; Sun, Yue; Hu, Gui-Lin; Niu, Ze-Jiaxin; Zhou, Hao-Wei; Zhang, Xi; Wang, Xin; Li, Chun-Hua; Chen, Fang-Yao; Gao, Ke; Zhang, Jie; Guan, Yong-Juan; Chang, John; Yang, Tie-Lin; Mu, Jian-Jun
• Is Part Of: Journal of hypertension. Volume 39:Issue 9(2021)
• Page Start: 1817
• Page End: 1825
• Publication Date: 2021-09-26
• Subjects: blood pressure -- gene polymorphism -- pregnancy-associated plasma protein-A2 -- salt -- salt sensitivity; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000002846
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Supplemental Digital Content is available in the text Abstract : Objective: Pregnancy-associated plasma protein-A2 (PAPP-A2) is the homolog of PAPP-A in the vertebrate genome and its role in protecting against salt-induced hypertension in salt-sensitive rats has been confirmed. We sought to examine the associations of plasma PAPP-A2 levels and its genetic variants with salt sensitivity, blood pressure (BP) changes and hypertension incidence in humans. Methods: Eighty participants (18–65 years old) sequentially consuming a usual diet, a 7-day low-salt diet (3.0 g/day) and a 7-day high-salt diet (18 g/day). In addition, we studied participants of the original Baoji Salt-Sensitive Study, recruited from 124 families in Northern China in 2004 who received the same salt intake intervention, and evaluated them for the development of hypertension over 14 years. Results: The plasma PAPPA2 levels significantly decreased with the change from baseline to a low-salt diet and decreased further when converting from the low-salt to high-salt diet. SNP rs12042763 in the PAPP-A2 gene was significantly associated with systolic BP responses to both low-salt and high-salt diet while SNP rs2861813 showed a significant association with the changes in SBP and pulse pressure at 14-year follow-up. Additionally, SNPs rs2294654 and rs718067 demonstrated a significant association with the incidence of hypertension over the 14-year follow-up. Finally, the gene-based analysis found that Pappa2 was significantly associated with longitudinal SBP changes and the incidence of hypertension over the 14-year follow-up. Conclusions: This study shows that dietary salt intake affects plasma PAPP-A2 levels and that PAPP-A2 may play a role in salt sensitivity, BP progression and development of hypertension in the Chinese populations.