Comparative Analgesic Properties of Bupivacaine, Etidocaine, and Lidocaine in Mice. Issue 2 (April 1984)

• Record Type: Journal Article
• Authors: Moore, Paul A.; Burney, Robert G.; Dunlevy, Harry A.
• Is Part Of: Regional anesthesia. Volume 9:Issue 2(1984)
• Page Start: 90
• Page End: 93
• Publication Date: 1984-04
• Subjects: Anesthetics -- bupivacaine -- etidocaine -- lidocaine -- Analgesia -- Pharmacokinetics -- Tests -- hot plate -- stretch -- mice; Conduction anesthesia -- Periodicals; Pain medicine -- Periodicals; 617.964
• DOI: 10.1136/rapm-00115550-198409020-00009
• Languages: English
• ISSNs: 0146-521X

Abstract

Abstract : The analgesic properties of bupivacaine, etidocaine, and lidocaine were compared following intraperitoneal injection in mice. Two evaluations of analgesia were employed: the hot plate test and the stretch test. Doses of 75% of their corresponding CD50 s produce analgesia greater than control and less than morphine sulfate 5 mg/kg. When differences in the pharmacokinetic properties of the agents are evaluated, the relative analgesic properties of the three local anesthetics appear nearly identical.