Clinical implications of Indocyanine Green Fluorescence Imaging-Guided laparoscopic lymphadenectomy for patients with gastric cancer: A cohort study from two randomized, controlled trials using individual patient data. (October 2021)

• Record Type: Journal Article
• Authors: Zhong, Qing; Chen, Qi-Yue; Huang, Xiao-Bo; Lin, Guang-Tan; Liu, Zhi-Yu; Chen, Jun-Yu; Wang, Hua-Gen; Weng, Kai; Li, Ping; Xie, Jian-Wei; Lin, Jian-Xian; Lu, Jun; Lin, Mi; Huang, Ze-Ning; Zheng, Chao-Hui; Huang, Chang-Ming
• Is Part Of: International journal of surgery. Volume 94(2021)
• Publication Date: 2021-10
• Subjects: Gastric cancer -- Lymphadenectomy -- Fluorescence -- Indocyanine green -- Diagnostic value; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; 617.005
• DOI: 10.1016/j.ijsu.2021.106120
• Languages: English
• ISSNs: 1743-9191

Abstract

Abstract: Background: The value of indocyanine green (ICG) fluorescence imaging in tracing metastatic lymph nodes (LNs) has rarely been reported. We aimed to evaluate the clinical implications of fluorescence imaging-guided lymphadenectomy and the sensitivity of fluorescent lymphography to detect metastatic LN stations in gastric cancer (GC). Materials and methods: This analysis pooled data from two randomized controlled trials (FUGES-012 and FUGES-019 studies) on laparoscopic ICG tracer-guided lymphadenectomy for GC between November 2018 and October 2020. Patients who received ICG injection using either the intraoperative subserosal or preoperative submucosal approaches 1 day before surgery and underwent fluorescence imaging-guided lymphadenectomy were defined as the ICG group. Patients who underwent conventional lymphadenectomy without ICG injection and intraoperative imaging were defined as the non-ICG group. Results: Among 514 enrolled patients, the ICG and non-ICG groups included 385 and 129, respectively. A significantly higher mean number of LNs was retrieved in the ICG group than in the non-ICG group (49.9 vs. 42.0, P < 0.001). The ICG group showed a lower LN noncompliance rate than that in the non-ICG group (31.9% vs. 57.4%, P < 0.001). The sensitivity of fluorescence imaging for detecting all metastatic LN stations was 86.8%. The negative predictive value was 92.2% for nonfluorescent stations. For detecting all metastatic stations, subgroup analysis revealed 97.7%, 91.7%, 86.2%, and 84.3% sensitivities for pT1, pT2, pT3, and pT4a tumors, respectively. Regardless of gastrectomy type, the diagnostic accuracy for detecting all metastatic stations in the D1+ and D2 stations for cT1–cT2 disease reached 100%. Conclusion: ICG fluorescence imaging, using either the subserosal or submucosal approaches, assisted in the thorough dissection of potentially metastatic LNs, as recommended for individualized laparoscopic lymphadenectomy for GC. Highlights: ● Indocyanine green (ICG) fluorescence imaging can assist surgeons in the thorough dissection of metastatic lymph nodes of gastric cancer. ● For pT1 tumors, the sensitivity of fluorescence imaging for detecting all metastatic stations was 97.7%. The negative predictive value for nonfluorescent stations was 99.7%. ● ICG imaging is recommended for use in selective fluorescent station-based lymphadenectomy for patients with cT1–cT2 tumors ● ICG imaging is recommended for use in systematic fluorescent imaging-guided lymphadenectomy for patients with cT3–cT4a tumors.