Front Cover: Aryl Fluoroalkyl Sulfoxides: Optical Stability and pKa Measurement (Eur. J. Org. Chem. 36/2021). Issue 36 (16th September 2021)

• Record Type: Journal Article
• Authors: Messara, Amélia; Vanthuyne, Nicolas; Diter, Patrick; Elhabiri, Mourad; Panossian, Armen; Hanquet, Gilles; Magnier, Emmanuel; Leroux, Frédéric R.
• Is Part Of: European journal of organic chemistry. Issue 36(2021)
• Page Start: 5017
• Page End: 5017
• Publication Date: 2021-09-16
• Subjects: Absorption -- Acidity -- Enantiomerization -- Fluorine -- Sulfoxide; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202100935
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Front Cover shows the introduction of fluorinated groups into molecules, which gives them interesting and sometimes unexpected physicochemical properties and reactivity. In this study, the configurational stability of fluoroalkyl sulfoxides (shown on the flyer) was investigated and the pKa value of the ‐CHF2 group was determined, which is very important for medicinal and agrochemical research. The picture is reminiscent of "Kinder Surpise"® where the sulfoxide appears as an exciting molecular toy and the surprises are the physical data determined because nothing was known before about this type of compounds (copyright of the illustration by J.‐F. Nierengarten). More information can be found in the Full Paper by G. Hanquet, E. Magnier, F. R. Leroux et al .